There's already been abundant research on the matter: The connection between being damaged and being wildly talented. Among others, Drs. Julian Lieb, Kay Redfield Jamison and John Gartner have published on the subject.
In the current edition of NEW YORK Magazine, Robert Kolker profiles a living example of that: David Letterman. From all that emotional dysfunction within Letterman probably emerged his ability to survive the worst crisis of his career. Actually, the sex scandal might have enhanced his marketability. White-bread sponsors such as Disney didn't flee when the Love Den tales hit the media.
The same sort of tale of deep damage gets told about Charles Dickens, The House of Wittegenstein [including Ludwig], and John Nash. Yet too many parents, therapists, employers, and spouses try to make the wounded "normal." Strange, given the evidence that talent is a harsh task-master and realizing its potential requires whatever.
A more doable as well as useful goal for those associated with extreme ability would be to simply keep them functioning and out of harm's way. That's probably why Letterman gravitates toward smart women - who have his number. They can keep him on the kind of leash he needs to be on.
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