Hank is neutralized because he realizes his status as lawman has been poisoned by the money from the meth operation. Skyler and Walt inform him they had paid his medical bills with it.
Jesse gets it that Walt was likely the one who poisoned the little boy Brock. He sets off and pours gasoline all over Walt's house.
And Walt's relationships with everyone, including himself, are poisoned by his mad drive for power. He can't be a father. He can't be a husband. He can't be self-aware.